Perioperative medicine & outcomes
Retrospective Analysis of the Association of Preoperative Sex Hormone Therapy With the Development of Postoperative Acute Kidney Injury
Authors' conclusion
Preoperative antiandrogen therapy in men and vaginal estrogen therapy in women older than 55 years were associated with reduced odds of postoperative AKI after noncardiac surgery.
Study context
- Population
- Women >55 years and men >18 years undergoing noncardiac or cardiac surgery, Duke University Medical Center, 2013–2023 (excluding missing creatinine, CKD stage 5, transplant and minor cases)14,086 cardiac surgery
- Participants
- 82,557 women
- Exposure
- Preoperative exogenous sex hormone therapy vs no sex hormone therapy
- Outcome
- Postoperative AKI (KDIGO serum creatinine criteria)
Methodological detailssingle-centre, multivariable logistic regression
- Single-centre
- Multivariable logistic regression
Main finding
As reported in the abstract
Postoperative AKI after noncardiac surgery
Each group vs no sex hormone therapyEstimate (95% CI)P value
Antiandrogensmen, noncardiac surgery
OR 0.83(0.72–0.96)
P < 0.01Vaginal estrogenwomen, noncardiac surgery
aOR 0.61(0.47–0.79)
P < 0.001Observational data: associations, not effects.
Further findings
Postoperative acute kidney injury (AKI) after cardiac surgery
- Neither male nor female sex hormone exposures associated with AKI risk after cardiac surgery
Original publication
Retrospective Analysis of the Association of Preoperative Sex Hormone Therapy With the Development of Postoperative Acute Kidney Injury. Anesth Analg. Published 23 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →