Retrospective Chart Review of Euglycemic Diabetic Ketoacidosis Rates and Outcomes Postimplementation of Sodium Glucose Cotransporter 2 Inhibitor Use Stoppage 5 Days Before Open Heart Surgery
Authors' conclusion
Postoperative eDKA was absent in SGLT2i patients told to stop medications 5 days before open heart surgery. LOS and infection and mortality rates appeared similar between the two cohorts.
Study context
- Population
- Adult open heart surgery patients, academic university hospital, 12/14/2022 to 10/25/2023
- Participants
- 540 patients
- Exposure
- SGLT2i stopped 5 days before open heart surgery vs non-SGLT2i users
- SGLT2in = 48
- Outcome
- eDKA development
- Follow-up
- Within 24 hours of hospital admission
Methodological detailssingle-centre, chart review
- Single-centre
- Chart review
Main finding
As reported in the abstract
eDKA within 24 h of hospital admission
SGLT2i
0%
0 of 48
Observational data: associations, not effects.
Further findings
Hospital LOS · medians; means p = 0.03
P = 0.003
Mean (SD) SGLT2i 4 [3] · Non-SGLT2i 5 [2]
CVICU LOS
P = 0.14
In-hospital mortality
P = 0.3
Hospital LOS
- Hospital LOS statistically longer with SGLT2i use
Safety
Sternal infections
P > 0.9
Original publication
Retrospective Chart Review of Euglycemic Diabetic Ketoacidosis Rates and Outcomes Postimplementation of Sodium Glucose Cotransporter 2 Inhibitor Use Stoppage 5 Days Before Open Heart Surgery. J Cardiothorac Vasc Anesth. Published 22 February 2025. doi:10.
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