Pediatric anesthesia & critical care
Retrospective Review of Intraoperative Hypotension and Perioperative Angiotensin Inhibitor Use in Pediatrics
Main finding · Incidence of hypotension (before matching)Result — go to the resultOdds ratio 0.73 CI 0.48–1.10Authors' conclusion
We found no evidence to support the practice of abstaining from angiotensin inhibitor use in pediatric surgical patients for concern of intraoperative hypotension.
Study context
- Population
- Pediatric surgical patients on angiotensin inhibitor therapy184 per group after matching
- Participants
- 490 patients
- Exposure
- Angiotensin inhibitor within 2 days vs 2–30 days before surgery
- Recentsn = 232
- Remotesn = 258reference
- Outcome
- Intraoperative hypotension
Methodological detailssingle-centre, propensity-score matched, covariate-adjusted logistic regression
- Single-centre
- Propensity-score matched
- Covariate-adjusted logistic regression
Main finding
Incidence of hypotension (before matching)
Odds ratio
0.73
CI 0.48–1.10
P = 0.129
Events by group
Recents vs Remotes
OR 0.73 (CI 0.48–1.10); P = 0.129
As reported in the abstract
- Overall incidence of hypotension
- 29%
Observational data: associations, not effects.
Further findings
Incidence of hypotension (propensity-score matched) · no difference
P = 0.13
- Incidence of hypotension (propensity-score matched): matched cohort, 184 per group
Original publication
Retrospective Review of Intraoperative Hypotension and Perioperative Angiotensin Inhibitor Use in Pediatrics. Paediatr Anaesth. Published 27 June 2025. doi:10.
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