Hemodynamics, fluids & transfusion
Norepinephrine infusion for preventing hypotension during hepatic exteriorization in Kasai portoenterostomy in infants with biliary atresia: A randomized controlled trial
Primary result · Persistent hypotension during liver exteriorization (need for liver release after IV fluid and vasopressor boluses)Result — go to the resultRelative risk 0.17 95% CI 0.04–0.63Authors' conclusion
Among infants with biliary atresia undergoing Kasai portoenterostomy operation, norepinephrine infusion significantly reduced the incidence of persistent severe hypotension during hepatic exteriorization requiring liver release.
Study context
- Population
- Infants with biliary atresia scheduled for Kasai portoenterostomy
- Participants
- 32 infants
- Comparison
- Norepinephrine vs Control
- Primary endpoint
- Hypotension during liver exteriorization (persistent mean arterial pressure (MAP) reduction ≥20% of baseline requiring release of the liver)
Methodological detailsplacebo-controlled
- Placebo-controlled
Primary result
As reported in the abstract
Persistent hypotension during liver exteriorization (need for liver release after IV fluid and vasopressor boluses)
Relative risk
0.17
95% CI 0.04–0.63
P = 0.001
Events by treatment group
Norepinephrine vs Control
RR 0.17 (95% CI 0.04–0.63); P = 0.001
Further findings
| Outcome | Norepinephrine | Control | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| Use of rescue norepinephrine boluses | 18.8% | 81.3% | 0.23 (0.08–0.66) | P = 0.001 | |
| 0.050.21520Relative risk (log scale) |
Original publication
Norepinephrine infusion for preventing hypotension during hepatic exteriorization in Kasai portoenterostomy in infants with biliary atresia: A randomized controlled trial. Anaesth Crit Care Pain Med. Published 16 April 2025. doi:10.
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