Cardiothoracic & vascular anesthesia
Prophylactic norepinephrine infusion to reduce severe hypotension during induction of anaesthesia in patients undergoing cardiac surgery: a randomised controlled single-centre clinical trial
Primary resultResult — go to the resultOdds ratio 0.96 95% CI 0.56–1.66Authors' conclusion
In patients undergoing cardiac surgery, infusion of norepinephrine before general anaesthesia at a starting dose of 0.06 μg kg-1 min-1 did not reduce severe hypotension compared with on-demand ephedrine.
Study context
- Population
- Patients undergoing cardiac surgery, induction of GA and tracheal intubationrandomised and analysed (ITT)
- Participants
- 210 patients
- Comparison
- Prophylactic norepinephrine infusion vs on-demand ephedrine
- Primary endpoint
- Occurrence of MAP <55 mm Hg (severe hypotension)
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
Odds ratio
0.96
95% CI 0.56–1.66
P = 0.99
By group
Norepinephrine vs Control
OR 0.96 (95% CI 0.56–1.66); P = 0.99
Further findings
| Outcome | Norepinephrine | Control | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| MAP <65 mm Hg | 63.8% | 78.1% | 0.49 (0.26–0.90) | P = 0.02 | |
| 0.20.5125Odds ratio (log scale) |
Safety
| Outcome | Norepinephrine | Control | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Intubation-related complications | 22.9% | 32.4% | 0.62 (0.33–1.14) | P = 0.13 | |
| 0.20.5125Odds ratio (log scale) |
Postoperative outcomes (AKI, time on ventilator, ICU LOS)
- No difference between groups
Original publication
Prophylactic norepinephrine infusion to reduce severe hypotension during induction of anaesthesia in patients undergoing cardiac surgery: a randomised controlled single-centre clinical trial. Br J Anaesth. Published 11 December 2025. doi:10.
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