Cardiothoracic & vascular anaesthesia
Elevated Cardiopulmonary Bypass Flow for Renal Protection in Cardiac Surgery: A Randomized Trial
Authors' conclusion
Increasing CPB flow by 20% reduced renal injury biomarkers and postoperative creatinine and improved early hemodynamic stability.
Study context
- Population
- Adults undergoing elective cardiac surgery with cardiopulmonary bypass (CPB); Mean arterial pressure (MAP) maintained at 60 to 80 mm Hg with norepinephrine
- Participants
- 89 adults
- Comparison
- High-flow vs standard-flow during CPB
- High-flown = 45
- Standard-flown = 44reference
- Primary endpoint
- Urine biomarkers of renal injury: NAG and [TIMP-2 × IGFBP-7] levels
- Follow-up
- 60 minutes post-CPB
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
Urine renal injury biomarkers
Each group vs standard-flowEstimate (95% CI)P value
High-flow
geometric mean ratio(NAG) 0.43 (0.26–0.70)
P < 0.001High-flow
geometric mean ratio([TIMP-2 × IGFBP-7]) 0.46 (0.30–0.73)
P < 0.001Further findings
| Outcome | High-flow | Standard-flow | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| AKI incidence | 16% | 25% | 1.90 (0.64–5.60) | P = 0.248 | |
| 0.20.5125Odds ratio (log scale) |
Serum creatinine · first 3 postoperative days
- Median S-creatinine remained below baseline in the high-flow group and above baseline in the standard-flow group
Norepinephrine dose · intraoperatively and up to 4 hours after CPB
- Significantly reduced in the high-flow group
Fluid balance
- No significant difference
Safety
Bleeding and adverse events
- No significant differences
Original publication
Elevated Cardiopulmonary Bypass Flow for Renal Protection in Cardiac Surgery: A Randomized Trial. Anesth Analg. Published 10 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →