Reversal of neuromuscular blockade with sugammadex based on the residual amount of rocuronium in the body using pharmacokinetic simulation: A single-centre observational study
Authors' conclusion
Based on pharmacokinetic simulation, all patients successfully recovered from NMB using rocuronium, and excellent recovery profiles were achieved.
Study context
- Population
- Patients without cardiac, hepatic, renal or neuromuscular disorders scheduled for elective surgery, Osaka University Hospital, Japananalysed
- Participants
- 123 patients
- Comparison
- Sugammadex 2 mg kg −1 (control) vs four, six or eight times the residual amount of rocuronium (pharmacokinetic simulation)
- Primary endpoint
- Recovery time from sugammadex administration to train-of-four (TOF) ratio of 0.9
Methodological detailssingle-centre, four-group, single-blind, Design stated as observational study in the abstract's DESIGN section
- Single-centre
- Four-group
- Single-blind
- Design stated as observational study in the abstract's DESIGN section
Primary result
As reported in the abstract
Recovery time to TOF ratio 0.9
P = 0.21
Further findings
Sugammadex dose administered — Control vs Four times, Six times, Eight times
P < 0.01
Safety
- All 123 analysed patients successfully extubated
- No signs of recurarisation observed
Original publication
Reversal of neuromuscular blockade with sugammadex based on the residual amount of rocuronium in the body using pharmacokinetic simulation: A single-centre observational study. Eur J Anaesthesiol. Published 3 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →