Neuroanesthesia & neurocritical care
Risk factors associated with acute kidney injury in patients with traumatic brain injury: A systematic review and meta-analysis
Study context
- Population
- Traumatic brain injury (TBI) patients (observational studies published in English up to October 2024)
- Participants
- 13,115 patients · 20 studies
- Comparison
- Risk factors for AKI in TBI patients
- Outcome
- Risk factors associated with AKI
Methodological detailsrandom-effects model when I2 > 50 %, fixed-effects model when I2 < 50 %, Newcastle-Ottawa Scale risk of bias, GRADE certainty of evidence
- Random-effects model when I2 > 50 %, fixed-effects model when I2 < 50 %
- Newcastle-Ottawa Scale risk of bias
- GRADE certainty of evidence
Pooled result
As reported in the abstract
Risk factors for AKI
Odds ratio (95 % CI)
Male genderI2 0 %
1.43(1.21–1.70)
DiabetesI2 0 %
3.59(1.74–7.42)
GCS ≤ 8 at admissionI2 0 %
1.56(1.28–1.90)
Mannitol useI2 74 %
2.14(1.08–4.25)
Vancomycin useI2 0 %
1.75(1.35–2.27)
RBC transfusionI2 59 %
3.35(1.86–6.04)
MD (95 % CI)
GCSI2 38 %
−0.48(−0.74,−0.23)
SAPS II scoreI2 56 %
4.65(2.69–6.61)
Serum creatinine at admissionI2 93 %
18.17(1.82–34.51)
HemoglobinI2 79 %
−6.82(−12.72 to −0.92)
GlucoseI2 0 %
1.42(0.64–2.20)
Further pooled results
Pooled incidence of AKI after TBI
- Pooled incidence
- 19 % (95 % CI 16-23)
Original publication
Risk factors associated with acute kidney injury in patients with traumatic brain injury: A systematic review and meta-analysis. J Crit Care. Published 22 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →