Neuroanesthesia & neurocritical care
Lassen’s Cerebral Autoregulation Plot Revisited and Validated 65 Years Later: Impacts of Vasoactive Drug Treatment on Cerebral Blood Flow
Authors' conclusion
These insights underscore the importance of individualized blood pressure management guided by modern data in the context of cerebral autoregulation across varied patient populations.
Study context
- Population
- Studies published since 2000 on mean arterial pressure (MAP) and cerebral blood flow (CBF) (awake humans with normal brains, critically ill, TBI, anesthetized patients)
- Outcome
- Validation of Lassen's cerebral autoregulation plot (CBF vs MAP) using contemporary data
Main finding
As reported in the abstract
Cerebral autoregulation plateau
- Plateau confirmed: CBF relatively stable across a specific MAP range in awake humans with normal brains
- Significant variations in cerebral autoregulation among different populations
- In critically ill and TBI patients the autoregulatory plateau dissipates
- Plateau observed with IV anesthetic agents but not with volatile agents
Further findings
Effect of vasopressors on CBF
- Increased CBF in critically ill patients but not in awake humans with normal brains
- Greater increase in CBF during volatile than IV anesthesia
Effect of modern antihypertensives on CBF
- No significant impact on CBF; smaller impact than in historical data
Original publication
Lassen’s Cerebral Autoregulation Plot Revisited and Validated 65 Years Later: Impacts of Vasoactive Drug Treatment on Cerebral Blood Flow. Anesth Analg. Published 4 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →