Hemodynamics, fluids & transfusion
Individualized mean arterial pressure targets in critically ill patients guided by non-invasive cerebral-autoregulation: a scoping review
Authors' conclusion
Preliminary investigations suggest considerable variability in personalized MAP targets, which may explain differences in clinical outcomes among critically ill populations.
Study context
- Population
- Critically ill patients with personalized mean arterial pressure (MAP) targets guided by non-invasive cerebral autoregulation monitoringstudies included
- Participants
- 49 patients
- Outcome
- Characteristics of included studies of personalized MAP targets guided by non-invasive cerebral autoregulation (design, population, reported targets, data loss)
Methodological detailsPRISMA-ScR, Search of Ovid MedLine, Embase and Cochrane Library on September 28, 2023; 2 independent reviewers
- PRISMA-ScR
- Search of Ovid MedLine, Embase and Cochrane Library on September 28, 2023; 2 independent reviewers
Main finding
As reported in the abstract
- Studies included (of 7,738 identified)
- 49
- Observational studies
- 45 (92%)
- Interventional studies
- 4 (8%)
- Cardiac surgery populations
- 26, 53%
- Non-cardiac major surgery populations
- 4, 8%
- Cardiac arrest populations
- 8, 16%
- Brain injury populations
- 7, 14%
- Respiratory failure and shock populations
- 3, 6%
- Sepsis populations
- 3, 6%
- Optimal MAP reported
- 24 (49%)
- Lower limit of autoregulation reported
- 23 (47%)
- Upper limit of autoregulation reported
- 10 studies (20%)
- Studies reporting partial data loss (software failures, anomalous data, insufficient natural MAP fluctuation, workflow barriers)
- 34
Further findings
Feasibility in randomized controlled trials (RCTs)
- Challenges with maintaining patients within target range
Demographic predictors of personalized targets
- Studies investigating demographic predictors; only few predictors identified
- 10
Original publication
Individualized mean arterial pressure targets in critically ill patients guided by non-invasive cerebral-autoregulation: a scoping review. Crit Care. Published 16 May 2025. doi:10.
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