Cardiothoracic & vascular anesthesia
Optimal brain perfusion pressure derived from the continuous monitoring of cerebral autoregulation status during neonatal heart surgery under cardiopulmonary bypass in relation to brain injury: An observational study
Authors' conclusion
The study provides valuable insights into the intricate relationship between intraoperative cerebral hemodynamics and post-operative brain injury.
Study context
- Population
- Neonates undergoing heart surgery under cardiopulmonary bypass (CPB), monitored with near-infrared spectrometry and mean arterial pressure (MAP)
- Participants
- 38 neonates
- Exposure
- Abnormal MRI vs No brain injury
- Abnormal MRIn = 17
- Outcome
- Time spent below the LLA during CPB
- Follow-up
- During CPB
Main finding
As reported in the abstract
P = 0.039
Observational data: associations, not effects.
Further findings
| Outcome | pre-CPB | During CPB | P value |
|---|---|---|---|
| CAR disruption at CPB onset (mean COx) | mean 0.16 ± 0.11 | mean 0.39 ± 0.37 | P < 0.001 |
Moderate to severe brain lesions post-operatively
- Neonates with moderate to severe brain lesions, out of 38
- 17 (45%)
LLA identified · before, during and after CPB
- LLA identified before CPB
- 31 out of 38 (82%)
- LLA identified during CPB
- 23 out of 38 (61%)
- LLA identified after CPB
- 14 out of 38 (37%)
ULA identified · before, during and after CPB
- ULA identified before CPB
- 29 out of 38 (76%)
- ULA identified during CPB
- 22 out of 38 (58%)
- ULA identified after CPB
- 14 out of 38 (37%)
Time spent above the ULA
- No differences between patients with and without brain injury
Original publication
Optimal brain perfusion pressure derived from the continuous monitoring of cerebral autoregulation status during neonatal heart surgery under cardiopulmonary bypass in relation to brain injury: An observational study. Anaesth Crit Care Pain Med. Published 26 March 2025. doi:10.
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