Risk factors for COVID-19-associated pulmonary aspergillosis: a systematic review and meta-analysis
An erratum to this article was published (Lancet Respir Med, Jul 2024 ↗)
Study context
- Population
- Adults (aged >18 years) with COVID-1927 articles
- Participants
- 6,848 adults
- Comparison
- COVID-19 patients with CAPA vs without aspergillosis
- CAPAn = 1,324
- Outcome
- Factors associated with CAPA
Methodological detailsrandom-effects models, Mantel-Haenszel method, inverse variance method, Five databases searched, Dec 1, 2019, to July 27, 2023, Two reviewers independently screened and extracted data, Publication bias assessed with funnel plots
- Random-effects models
- Mantel-Haenszel method
- Inverse variance method
- Five databases searched, Dec 1, 2019, to July 27, 2023
- Two reviewers independently screened and extracted data
- Publication bias assessed with funnel plots
Pooled result
As reported in the abstract
Risk factors for CAPA (CAPA vs without CAPA)
Odds ratio (95% CI)P value
Chronic liver diseaseI2=53%
2.70(1.21–6.04)
P = 0.02Haematological malignanciesI2=50%
2.47(1.27–4.83)
P = 0.008COPDI2=26%
2.00(1.42–2.83)
P < 0.0001Cerebrovascular diseaseI2=46%
1.31(1.01–1.71)
P = 0.05Invasive mechanical ventilationI2=69%
2.83(1.88–4.24)
P < 0.0001RRTI2=14%
2.26(1.76–2.90)
P < 0.0001Interleukin-6 inhibitorsI2=89%
2.88(1.52–5.43)
P = 0.001CorticosteroidsI2=66%
1.88(1.28–2.77)
P = 0.001- Eight risk factors for CAPA identified
- 8
Further pooled results
Mean, years
| Outcome | CAPA | Without CAPA | Mean difference (CI) | P value | |
|---|---|---|---|---|---|
| AgeI2=86% | 66.6 (SD 3.6) | 63.5 (SD 5.3) | 2.90 (1.48–4.33) | P < 0.0001 | |
| −20246Difference (linear scale) |
Mean, days
| Outcome | CAPA | Without CAPA | Mean difference (days) (CI) | P value | |
|---|---|---|---|---|---|
| Duration of mechanical ventilationI2=88% | 19.3 (SD 8.9) | 13.5 (SD 6.8) | 5.53 (1.30–9.77) | P = 0.01 | |
| −50510Difference, days (linear scale) |
| Outcome | OR (CI) | P value | |
|---|---|---|---|
| All-cause mortality (post-hoc analysis)I2=51% · post-hoc analysis | 2.65 (2.04–3.45) | P < 0.0001 | |
| 0.20.5125Odds ratio (log scale) |
- CAPA diagnosis rate
- 19.3% · 1324
- CAPA diagnosis rate — Diagnosis rates ranged from 2.5% (14 of 566) to 47.2% (58 of 123)
- 2.5%–47.2%
- Duration of mechanical ventilation: n=7 studies
- All-cause mortality (post-hoc analysis): n=20 studies
Original publication
Risk factors for COVID-19-associated pulmonary aspergillosis: a systematic review and meta-analysis. Lancet Respir Med. Published 4 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →