Risks and benefits of oral modified‐release compared with oral immediate‐release opioid use after surgery: a systematic review and meta‐analysis
Pooled result · Pain intensityResult — go to the resultSMD 0.2 95% CI 0.04–0.37Authors' conclusion
Modified-release opioid use was associated with a higher incidence of adverse events (n = 645, odds ratio (95%CI) 2.76 (1.52-5.04)) and worse pain (n = 550, standardised mean difference (95%CI) 0.2 (0.04-0.37)) compared with immediate-release opioid use following surgery.
Study context
- Population
- Adults who underwent surgery8 articles: 5 RCTs, 3 observational
- Comparison
- Oral modified-release vs oral immediate-release opioids after surgery
- Outcome
- Safety (incidence of adverse events) and efficacy (pain intensity, analgesic and opioid use, physical function)
- Follow-up
- Up to 12 months postoperatively
Methodological detailsnarrative synthesis
- Narrative synthesis
Pooled result
Pain intensity
SMD
0.2
95% CI 0.04–0.37
Modified-release vs Immediate-release
SMD 0.2 (95% CI 0.04–0.37)
As reported in the abstract
Further pooled results
LOS and hospital readmission
- No superiority of modified-release (narrative synthesis)
Psychological function, costs, quality of life
- Not reported by any included study
Safety
| Outcome | OR (95% CI) | |
|---|---|---|
| Adverse eventsn = 645 | 2.76 (1.52–5.04) | |
| 0.20.5125Odds ratio (log scale) |
Persistent postoperative opioid use
- Higher with modified-release (one study)
Original publication
Risks and benefits of oral modified‐release compared with oral immediate‐release opioid use after surgery: a systematic review and meta‐analysis. Anaesthesia. Published 6 July 2023. doi:10.
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