Impact of modified‐release opioid use on clinical outcomes following total hip and knee arthroplasty: a propensity score‐matched cohort study
Main finding · Opioid-related adverse eventsResult — go to the resultDifference in proportions 7.8% 95% CI 2.3–13.3%Authors' conclusion
Modified-release opioid use was associated with an increased risk of harm when used for acute pain during hospitalisation after total hip or knee arthroplasty.
Study context
- Population
- Adult inpatients receiving opioid analgesia after total hip or knee arthroplasty, 3 tertiary metropolitan hospitals in Australia1:1 matched cohorts
- Participants
- 347 vs 347
- Exposure
- Modified-release opioids vs immediate-release opioids only
- Modified-release opioidsn = 347
- Immediate-release opioids onlyn = 347reference
- Outcome
- Incidence of opioid-related adverse events
- Follow-up
- During hospital admission
Methodological detailspropensity-score matched, multicentre
- Propensity-score matched
- Multicentre
Main finding
Opioid-related adverse events
Difference in proportions
7.8%
95% CI 2.3–13.3%
Events by group
Modified-release opioids vs Immediate-release opioids only
difference in proportions 7.8% (95% CI 2.3–13.3%)
As reported in the abstract
Observational data: associations, not effects.
Original publication
Impact of modified‐release opioid use on clinical outcomes following total hip and knee arthroplasty: a propensity score‐matched cohort study. Anaesthesia. Published 26 June 2023. doi:10.
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