Rocuronium dose and first-attempt intubation success in the critically ill: secondary analysis of two multicenter trials
Primary resultResult — go to the resultAdjusted relative risk 1.07 95% CI 1.02–1.12Authors' conclusion
In this secondary analysis, high-dose rocuronium (>1.2 mg/kg) was associated with higher first-attempt success.
Study context
- Population
- Adults undergoing emergency tracheal intubation in the emergency department (ED) and intensive care unit (ICU) (9 EDs, 24 ICUs, US)of 2440 trial patients
- Participants
- 1,822 adults
- Comparison
- High-dose vs standard-dose rocuronium
- High-dosen = 720
- Standard-dosen = 1,102reference
- Primary endpoint
- Successful intubation on the first attempt
Methodological detailspropensity-matched, stratified by setting
- Propensity-matched
- Stratified by setting
Primary result
As reported in the abstract
Adjusted relative risk
1.07
95% CI 1.02–1.12
High-dose vs Standard-dose
adjusted RR 1.07 (95% CI 1.02–1.12)
Further findings
| Outcome | Adjusted RR (95% CI) | |
|---|---|---|
| First-attempt success, ED intubations (subgroup) | 0.97 (0.89–1.04) | |
| First-attempt success, ICU intubations (subgroup) | 1.13 (1.06–1.20) | |
| 0.512Adjusted relative risk (log scale) |
Original publication
Rocuronium dose and first-attempt intubation success in the critically ill: secondary analysis of two multicenter trials. Am J Respir Crit Care Med. Published 18 May 2026. doi:10.
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