Perioperative medicine & outcomes
Role of supplemental regional blocks on postoperative neurocognitive dysfunction after major non-cardiac surgeries: a systematic review and meta-analysis of randomized controlled trials
Pooled resultResult — go to the resultOdds ratio 0.46 95% CI 0.35–0.59Authors' conclusion
Current evidence suggests that supplemental RAB are beneficial in preventing PNCD in patients after major non-cardiac surgery.
Study context
- Population
- Adults undergoing major non-cardiac surgery
- Participants
- 4,414 adults · 26 randomized controlled trials (RCTs)
- Comparison
- Supplemental regional analgesia blocks vs standard anesthesia care
- Outcome
- Incidence of postoperative neurocognitive dysfunction (PNCD)
- Follow-up
- Within 1 month of surgery
Methodological detailsrandom-effects model, GRADE certainty assessment
- Random-effects model
- GRADE certainty assessment
Pooled result
As reported in the abstract
Odds ratio
0.46
95% CI 0.35–0.59
P < 0.00001
RAB vs Control
OR 0.46 (95% CI 0.35–0.59); P < 0.00001
Further pooled results
Postoperative neurocognitive dysfunction (PNCD) by type: delirium and delayed neurocognitive recovery (subgroup)
- Prophylactic efficacy of regional analgesia blocks (RAB) persisted for both delirium and delayed neurocognitive recovery
Original publication
Role of supplemental regional blocks on postoperative neurocognitive dysfunction after major non-cardiac surgeries: a systematic review and meta-analysis of randomized controlled trials. Reg Anesth Pain Med. Published 19 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →