Perioperative medicine & outcomes
Postoperative pain and neurocognitive outcomes after noncardiac surgery: a systematic review and dose–response meta-analysis
Authors' conclusion
Dose-response meta-analyses found that postoperative pain intensity was associated with occurrence of and risk of developing POD.
Study context
- Population
- Adults undergoing noncardiac surgery
- Participants
- >9,000 adults · 30 studies
- Comparison
- Postoperative pain intensity and postoperative delirium (POD)/postoperative cognitive dysfunction (POCD)
- Outcome
- Association between acute postsurgical pain or CPSP and POD or POCD
Methodological detailsrandom-effects meta-analysis, GRADE certainty of evidence, Residual confounding and methodological variability prevented pooling of many studies and lowered certainty of evidence
- Random-effects meta-analysis
- GRADE certainty of evidence
- Residual confounding and methodological variability prevented pooling of many studies and lowered certainty of evidence
Pooled result
As reported in the abstract
POD per unit of postoperative pain intensity
Estimate (95% CI)
Per unit of pain intensity
aRR (occurrence of POD) 1.26(1.17–1.35)
Per unit of pain intensity
aRR (risk of developing POD) 1.18(1.08–1.30)
Per unit of pain intensity, as printed
Further pooled results
- Very low certainty of evidence for association between postoperative pain and POCD
- No studies assessed association between chronic postsurgical pain (CPSP) and POCD
Original publication
Postoperative pain and neurocognitive outcomes after noncardiac surgery: a systematic review and dose–response meta-analysis. Br J Anaesth. Published 11 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →