Perioperative medicine & outcomes
Associations between Alzheimer's disease biomarkers and postoperative delirium or cognitive dysfunction: A meta-analysis and trial sequential analysis of prospective clinical trials
Authors' conclusion
The study results indicate a negative correlation between preoperative CSF Aβ42 levels and the occurrence of both POD and POCD.
Study context
- Population
- Surgical patients aged at least 18 years15 studies
- Comparison
- Alzheimer's disease biomarkers in patients with vs without postoperative delirium (POD) or postoperative cognitive dysfunction (POCD)
- Outcome
- Association between perioperative Alzheimer's disease biomarkers and POD or POCD
Methodological detailsPRISMA, trial sequential analysis
- PRISMA
- Trial sequential analysis
Pooled result
As reported in the abstract
Preoperative CSF Aβ42 levels and POD / POCD
Preoperative cerebrospinal fluid (CSF) Aβ42 and onset of POD: MD (95% CI −114.15 to −58.05, I2 : 47%); negative correlation, strongly supported by trial sequential analysis (TSA)
−86.1
Preoperative CSF Aβ42 and incidence of POCD (95% CI −261.48 to −68.53, I2 : 95%); negative correlation, supported by TSA
−165.01
Further pooled results
Other Alzheimer's disease biomarkers (Aβ40, total tau (T-tau), phosphorylated tau (P-tau), Aβ42/T-tau ratio) and POD or POCD
- Evidence insufficient to confirm a relationship
Original publication
Associations between Alzheimer's disease biomarkers and postoperative delirium or cognitive dysfunction: A meta-analysis and trial sequential analysis of prospective clinical trials. Eur J Anaesthesiol. Published 1 December 2023. doi:10.
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