Pediatric anesthesia & critical care
Safety and efficacy of remimazolam tosilate for general anaesthesia in paediatric patients undergoing elective surgery: a multicentre, randomised, single‐blind, controlled trial
Primary result · Successful maintenance of anaesthesiaResult — go to the resultRate difference 1.4% 95% CI −2.9-5.8%Authors' conclusion
Remimazolam was well tolerated for the induction and maintenance of general anaesthesia in pre-school-age children and was non-inferior to propofol.
Study context
- Population
- Children aged 3–6 y, ASA 1 or 2, BMI 14–25 kg.m-2, undergoing elective surgery under GA with tracheal intubationanalysed
- Participants
- 187 children
- Comparison
- Remimazolam vs propofol for induction and maintenance of GA
- Remimazolamn = 140
- Propofoln = 47reference
- Primary endpoint
- Incidence of successful induction and maintenance of anaesthesia
Methodological detailsmulticentre, single-blind, 3:1 allocation
- Multicentre
- Single-blind
- 3:1 allocation
Primary result
Successful maintenance of anaesthesia
Rate difference
1.4%
95% CI −2.9-5.8%
P = 0.441
Events by treatment group
Remimazolam vs Propofol
rate difference 1.4% (95% CI −2.9-5.8%); P = 0.441
As reported in the abstract
Safety
Adverse events
Original publication
Safety and efficacy of remimazolam tosilate for general anaesthesia in paediatric patients undergoing elective surgery: a multicentre, randomised, single‐blind, controlled trial. Anaesthesia. Published 22 November 2024. doi:10.
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