Pediatric anesthesia & critical care
Pharmacokinetics of remimazolam after intravenous infusion in anaesthetised children
Authors' conclusion
Remimazolam in children was characterised by a high clearance and short context-sensitive half-time. When normalised to weight, pharmacokinetic properties were similar to those reported for adults.
Study context
- Population
- Children 2–6 yr, ASA 1–2, BMI 15–18 kg m-2, under GA with sevoflurane
- Participants
- Twenty-four children
- Outcome
- Pharmacokinetics of remimazolam and its metabolite CNS7054
Methodological detailspopulation pharmacokinetic modelling
- Population pharmacokinetic modelling
Main finding
As reported in the abstract
Pharmacokinetic parameters (median, Q25, Q75)
- Remimazolam clearance (ml kg-1 min-1), median (Q25, Q75)
- 15.9 (12.9, 18.2)
- Remimazolam central volume of distribution (L kg-1), median (Q25, Q75)
- 0.11 (0.08, 0.14)
- Remimazolam terminal half-life (min), median (Q25, Q75)
- 67 (49, 85)
- Remimazolam context-sensitive half-time after 4 h infusion (min), median (Q25, Q75)
- 17 (12, 21)
- CNS7054 clearance (ml kg-1 min-1), median (Q25, Q75)
- 0.89 (0.33, 1.40)
- CNS7054 central volume of distribution (L kg-1), median (Q25, Q75)
- 0.011 (0.005, 0.016)
- CNS7054 terminal half-life (min), median (Q25, Q75)
- 321 (230, 770)
Original publication
Pharmacokinetics of remimazolam after intravenous infusion in anaesthetised children. Br J Anaesth. Published 21 September 2023. doi:10.
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