Pediatric anesthesia & critical care
Safety of Levosimendan in Pediatric Patients: An Up-to-Date Systematic Review
Authors' conclusion
Hypotension and cardiac arrhythmia are the most reported side effects of levosimendan in pediatric patients.
Study context
- Population
- Pediatric patients receiving levosimendan in any setting
- Participants
- 1,271 patients · 48 studies
- Comparison
- Levosimendan vs control
- Levosimendann = 385
- Controln = 378reference
- Outcome
- Number and type of adverse side effects during levosimendan administration
Methodological detailsindependent screening and data extraction by two investigators
- Independent screening and data extraction by two investigators
Pooled result
As reported in the abstract
Adverse side effects (11 studies, 790 patients reporting)
Hypotension
≈28.9%
Arrhythmia, particularly tachycardia
about 12.3%
Further pooled results
| Outcome | Levosimendan | Control | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| All-cause mortality (meta-analysis of RCTs)I2 = 0% | 2.0% | 3.9% | 0.55 (0.25–1.21) | P = 0.14 | |
| 0.20.5125Relative risk (log scale) |
Original publication
Safety of Levosimendan in Pediatric Patients: An Up-to-Date Systematic Review. J Cardiothorac Vasc Anesth. Published 14 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →