Pediatric anesthesia & critical care
Seeking a Viable Alternative: A Prospective, Randomized, Controlled, Double‐Blind Non‐Inferiority Study of Oral Versus IV Dexamethasone in Children Undergoing Tonsillectomy
Primary result · Nausea in PACUResult — go to the resultAbsolute risk difference 4.8% 95% CI 1.6%–9.5%Authors' conclusion
Substituting oral dexamethasone in place of intravenous dexamethasone resulted in a non-inferior rate of PONV for pediatric patients undergoing tonsillectomy.
Study context
- Population
- Children aged 3 to 7 years undergoing tonsillectomy
- Participants
- 126 children
- Comparison
- Oral vs IV dexamethasone 0.5 mg/kg
- Oral dexamethasonen = 63
- Intravenous dexamethasonen = 63reference
- Primary endpoint
- PONV (non-inferiority of oral vs IV dexamethasone)
Methodological detailsprospective, double-blind, non-inferiority
- Prospective
- Double-blind
- Non-inferiority
Primary result
Nausea in PACU
Absolute risk difference
4.8%
95% CI 1.6%–9.5%
Oral dexamethasone vs IV dexamethasone
absolute risk difference 4.8% (95% CI 1.6%–9.5%)
As reported in the abstract
Secondary outcomes
| Outcome | Oral dexamethasone | Intravenous dexamethasone | Absolute risk difference (95% CI) | |
|---|---|---|---|---|
| Vomiting in PACU4 patients with vomiting, all oral (3.2%) | 6.3% (1.6%–11.1%) | |||
| Nausea and vomiting after discharge | 40% | 60% | −5.4% (−15.6% to 4.9%) | |
| −20−1001020Difference (linear scale) |
- Nausea and vomiting after discharge: percentages of the 15 patients reporting postoperative nausea and vomiting (PONV) after discharge
Original publication
Seeking a Viable Alternative: A Prospective, Randomized, Controlled, Double‐Blind Non‐Inferiority Study of Oral Versus IV Dexamethasone in Children Undergoing Tonsillectomy. Paediatr Anaesth. Published 8 September 2025. doi:10.
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