Neuroanesthesia & neurocritical care
Selective digestive tract decontamination in critically ill adults with acute brain injuries: a post hoc analysis of a randomized clinical trial
Primary result · In-hospital mortalityResult — go to the resultUnadjusted odds ratio 0.76 95% CI 0.63–0.92Authors' conclusion
In this post hoc analysis of a randomized clinical trial in critically ill patients with acute brain injuries receiving mechanical ventilation, the use of SDD significantly reduced in-hospital mortality in patients compared to standard care without SDD.
Study context
- Population
- Mechanically ventilated critically ill adults admitted to the intensive care unit (ICU) with acute brain injuries or conditionsall completed the trial
- Participants
- 2,061 participants
- Comparison
- SDD vs standard care
- SDDn = 968
- Standard caren = 1,093reference
- Primary endpoint
- In-hospital mortality within 90 days
- Follow-up
- 90 days
Methodological detailscrossover, cluster randomised
- Crossover
- Cluster randomised
Primary result
In-hospital mortality
Unadjusted odds ratio
0.76
95% CI 0.63–0.92
P = 0.004
Events by treatment group
SDD vs Standard care
unadjusted OR 0.76 (95% CI 0.63–0.92); P = 0.004
As reported in the abstract
Secondary outcomes
Death in ICU; ventilator-, ICU- and hospital-free days to day 90
- Statistically significant improvements in all four secondary outcomes with SDD vs standard care
Heterogeneity of treatment effect, patients with vs without acute brain injuries (subgroup)
- No significant heterogeneity of treatment effect
- Interaction p = 0.22
Original publication
Selective digestive tract decontamination in critically ill adults with acute brain injuries: a post hoc analysis of a randomized clinical trial. Intensive Care Med. Published 20 November 2023. doi:10.
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