Self-Reported Penicillin Allergy and antibiotic use in critical care: An observational, retrospective study
Authors' conclusion
SRPA was associated with a survival benefit that persisted after adjustment for confounders for unplanned ICU admissions.
Study context
- Population
- All intensive care unit (ICU) admissions over nine years, single centre
- Participants
- 35,319 admissions
- Exposure
- Self-Reported Penicillin Allergy (SRPA) vs non-SRPA
- Outcome
- 28-day mortality (time-to-event, multivariable adjusted for age, comorbidities, sex, admission SOFA score)
- Follow-up
- 28 days
Methodological detailssingle-centre, multivariable time-to-event analysis
- Single-centre
- Multivariable time-to-event analysis
Main finding
As reported in the abstract
28-day mortality
SRPA vs non-SRPAHazard ratio (95% CI)P value
Unplanned admissions, multivariable adjusted
0.76(0.68–0.86)
P < 0.001Planned admissions, multivariable adjusted
1.21(0.92–1.58)
P = 0.172Observational data: associations, not effects.
Further findings
Duration of antibiotics in ICU
P = 0.663
Baseline: female sex
P < 0.001
Median
| Outcome | SRPA | non-SRPA | P value |
|---|---|---|---|
| Antibiotic choice | P < 0.001 | ||
| Baseline: admission SOFA score | 3.5 | 3.5 | P = 0.839 |
Antibiotic choice
- SRPA significantly more likely to receive quinolones or other anti-Gram-positive antibiotics
Baseline: female sex
- SRPA had more comorbidities (p < 0.001)
Original publication
Self-Reported Penicillin Allergy and antibiotic use in critical care: An observational, retrospective study. Anaesth Crit Care Pain Med. Published 21 December 2024. doi:10.
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