Neuroanesthesia & neurocritical care
Sepsis is associated with radiological lesions in patients with primary brain injuries: The result of a bicentric retrospective cohort
Main finding · New or worsened brain lesionsResult — go to the resultAdjusted odds ratio 8.08 95% CI 3.28–11.29Authors' conclusion
The occurrence of I/S is associated with the extension of the initial lesion and/or the appearance of new brain lesions on MRI in patients hospitalized in the neurointensive care unit for primary brain injury.
Study context
- Population
- NeuroICU patients with primary brain injury who had two MRIs, January 2015–June 2020
- Participants
- 150 patients
- Exposure
- Infection or sepsis vs no I/S
- I/Sn = 50
- Controlsn = 100reference
- Outcome
- Composite:
- Increase in size of initial brain lesion
- Appearance of new brain lesions
Methodological detailsbicentric, propensity-score matched
- Bicentric
- Propensity-score matched
Main finding
New or worsened brain lesions
Adjusted odds ratio
8.08
95% CI 3.28–11.29
P < 0.001
By group
I/S vs Controls
aOR 8.08 (95% CI 3.28–11.29); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
ICU LOS
P < 0.0001
Unfavorable outcome (mRS ≥ 4) · discharge
P = 0.003
Unfavorable outcome (mRS ≥ 4) · 1 year
P = 0.037
- Microbleeds (I/S patients)
- 21.1%
Lesion types
- Ischemic strokes
- 44%
- Intraparenchymal hemorrhages
- 44%
- Diffuse leukoencephalopathy
- 52%
Sensitivity analysis, ventilated patients
- Results similar
Original publication
Sepsis is associated with radiological lesions in patients with primary brain injuries: The result of a bicentric retrospective cohort. Anaesth Crit Care Pain Med. Published 3 October 2025. doi:10.
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