Intracranial hemorrhage in patients treated for SARS-CoV-2 with extracorporeal membrane oxygenation: A systematic review and meta-analysis
Pooled result · ICHResult — go to the resultRelative risk 1.72 95% CI 1.23–2.42Authors' conclusion
This study suggests increased hemorrhage rates in COVID-19 patients on ECMO compared to similar controls.
Study context
- Population
- Patients treated with extracorporeal membrane oxygenation (ECMO), including for COVID-19
- Participants
- 4,000 patients · 54 studies
- Comparison
- COVID-19 vs non-COVID ECMO patients
- Outcome
- Intracranial hemorrhage (ICH) during ECMO
Methodological detailsall included studies retrospective, MINORS quality assessment, Risk of bias increased (MINORS), mainly due to retrospective designs
- All included studies retrospective
- MINORS quality assessment
- Risk of bias increased (MINORS), mainly due to retrospective designs
Pooled result
ICH
Relative risk
1.72
95% CI 1.23–2.42
COVID-19 vs Controls
RR 1.72 (95% CI 1.23–2.42)
As reported in the abstract
Further pooled results
| Outcome | With ICH | Without ICH | RR (95% CI) | |
|---|---|---|---|---|
| Mortality among COVID-19 patients on ECMO, with vs without ICH | 64.0% | 41% | 1.9 (1.44–2.51) | |
| 0.20.5125Relative risk (log scale) |
Original publication
Intracranial hemorrhage in patients treated for SARS-CoV-2 with extracorporeal membrane oxygenation: A systematic review and meta-analysis. J Crit Care. Published 11 May 2023. doi:10.
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