Pediatric anesthesia & critical care
Serum-integrated omics reveal the host response landscape for severe pediatric community-acquired pneumonia
Authors' conclusion
The integrated analysis of the proteome and metabolome might open up new ways in diagnosing and uncovering the complexity of severity of CAP.
Study context
- Population
- Children with community-acquired pneumonia (CAP) and healthy controlsverification cohort of 129
- Participants
- 20 / 15 / 15
- Comparison
- Severe CAP vs non-severe CAP vs healthy controls
- Severe CAPs (S-CAPs)n = 20
- Non-severe CAPs (NS-CAPs)n = 15
- Controls (CONs)n = 15reference
- Outcome
- Serum proteomic and metabolic signature
Methodological detailsintegrated proteomics and metabolomics, training and verification cohorts
- Integrated proteomics and metabolomics
- Training and verification cohorts
Main finding
As reported in the abstract
- Proteomic and metabolic signature markedly different between S-CAPs, NS-CAPs and CONs
- New serum biomarker panel (2 proteins: C-reactive protein (CRP), LBP; 3 metabolites: Fasciculol C, PE (14:0/16:1(19Z)), PS (20:0/22:6(4Z, 7Z, 10Z, 13Z, 16Z, 19Z))) developed to identify CAP and distinguish severe pneumonia
- Pathway analysis: activation of cell death pathway, dysregulated complement system, coagulation cascade and platelet function, and inflammatory responses as contributors to tissue damage in CAP
- Activation of glycolysis and higher nucleotide levels led to imbalanced deoxyribonucleotide pools contributing to severe CAP
- Dysregulated lipid metabolism identified as potential mechanism for severe progression of CAP
Original publication
Serum-integrated omics reveal the host response landscape for severe pediatric community-acquired pneumonia. Crit Care. Published 1 March 2023. doi:10.
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