Severe dengue in adults admitted to intensive care units on réunion island: clinical spectrum, outcomes, and predictors of mortality
Authors' conclusion
SD on Réunion Island exhibited a wide clinical spectrum in ICUs and was associated with substantial mortality, primarily due to multiple organ failure rather than hemorrhagic complications. Co-infections were common, and comorbidities likely contributed to unfavorable outcomes.
Study context
- Population
- Adults admitted to the five intensive care units (ICUs) of Réunion Island, January 2017–December 2022, with laboratory-confirmed severe dengue (US CDC criteria)
- Participants
- 137 severe dengue ICU admissions
- Outcome
- In-hospital mortality
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
In-hospital mortality rate
25%
Catecholamine use, independent predictor of mortality (OR [CI], P)
OR 4.71
1.58–14.07p = 0.005
Respiratory rate at admission, independent predictor of mortality (OR [CI], P)
OR 1.10
1.03–1.17p = 0.004
Observational data: associations, not effects.
Further findings
ICU admission rate among confirmed dengue cases
- Confirmed dengue cases
- 72.434
- Required hospitalization
- 2.817
- ICU admissions per 1,000 infections
- 1.8
Clinical spectrum
- Median age, years (IQR 50-70)
- 63
- Male
- 62%
- Circulatory failure
- 62%
- Distributive shock
- 12%
- Myocarditis
- 9%
- Veno-arterial extra corporeal membrane oxygenation (VA-ECMO) required (patients)
- 6
- Hepatic failure
- 50%
- Renal failure
- 59%
- Neurological presentations, 13 patients
- 9%
- Co-infection
- 33%
- Initial diagnosis other than dengue, 52 patients
- 38%
- Thrombocytopenia
- 78%
- Hemorrhagic events uncommon
Original publication
Severe dengue in adults admitted to intensive care units on réunion island: clinical spectrum, outcomes, and predictors of mortality. Crit Care. Published 27 November 2025. doi:10.
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