Pediatric anesthesia & critical care
Severe Sepsis During Treatment for Childhood Leukemia and Sequelae Among Adult Survivors
Main finding · Moderate to severe neurocognitive impairmentResult — go to the resultAdjusted hazard ratio 1.86 95% CI 1.61–2.16Authors' conclusion
In this cohort study of long-term outcomes in survivors of pediatric leukemia, severe sepsis during anticancer therapy for leukemia was associated with a selectively increased risk for development of serious neurocognitive sequelae.
Study context
- Population
- Adult survivors of childhood leukemia diagnosed 1985–2010, excluding hematopoietic cell transplant or relapsed leukemia
- Participants
- 644 survivors
- Exposure
- Severe sepsis vs no severe sepsis during childhood leukemia therapy
- Severe sepsisn = 46
- No severe sepsisn = 598reference
- Outcome
- Cumulative incidence of CTCAE-defined chronic health conditions (cardiovascular, pulmonary, kidney, neurological, neurocognitive)
Methodological detailsinverse propensity score weighting, St Jude Lifetime Cohort Study
- Inverse propensity score weighting
- St Jude Lifetime Cohort Study
Main finding
Moderate to severe neurocognitive impairment
Adjusted hazard ratio
1.86
95% CI 1.61–2.16
P < 0.001
Events by group
Severe sepsis vs No severe sepsis
aHR 1.86 (95% CI 1.61–2.16); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Original publication
Severe Sepsis During Treatment for Childhood Leukemia and Sequelae Among Adult Survivors. JAMA Netw Open. Published 4 March 2024. doi:10.
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