Cardiac arrest & resuscitation
Sex differences in out-of-hospital cardiac arrest: the impact of comorbidities on first monitored rhythm
Authors' conclusion
Women showed lower shockable initial rhythm rates than men after OHCA, a disparity not solely explained by age and resuscitation conditions.
Study context
- Population
- Adults with out-of-hospital cardiac arrest (OHCA) of presumed medical cause in Denmark, 2016–2021
- Participants
- 22,943 adults
- Exposure
- Women vs men
- Outcome
- Shockable initial rhythm
Methodological detailsnationwide
- Nationwide
Main finding
As reported in the abstract
- Men twice as likely as women to present with shockable initial rhythm; persisted in matched cohort and in subset with identical resuscitation conditions
- Women showed earlier and steeper decline in shockable initial rhythm rates around age 45
- Matched cohort
Observational data: associations, not effects.
Further findings
| Outcome | Women | Men |
|---|---|---|
| Comorbidities and shockable initial rhythm, by sex (interaction analyses) | ||
| Substance use disorders OR | 0.71 | 0.42 |
| AF OR | 1.95 | 1.54 |
- Comorbidities and shockable initial rhythm, by sex (interaction analyses): Substance use disorders p < 0.005
- Comorbidities and shockable initial rhythm, by sex (interaction analyses): AF p < 0.05
Original publication
Sex differences in out-of-hospital cardiac arrest: the impact of comorbidities on first monitored rhythm. Resuscitation. Published 11 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →