Hemodynamics, fluids & transfusion
Sex differences in treatments and outcomes of patients with cardiogenic shock: a systematic review and epidemiological meta-analysis
Pooled result · Combined in-hospital and 30-day mortality, unadjustedResult — go to the resultOdds ratio 1.35 95% CI 1.26–1.44Authors' conclusion
Even when adjusted for confounders, mortality for cardiogenic shock in women is approximately 10% higher than men. This effect is seen in both acute myocardial infarction and heart failure cardiogenic shock. Women with cardiogenic shock are less likely to be treated with mechanical circulatory support than men.
Study context
- Population
- Adults with cardiogenic shock81 studies
- Participants
- 656,754 vs 1,018,036
- Comparison
- Women vs men
- Womenn = 656,754
- Menn = 1,018,036reference
- Outcome
- Combined in-hospital and 30-day mortality
- Follow-up
- 30-day
Methodological detailsepidemiological meta-analysis, Cochrane Central, PubMed, MEDLINE and EMBASE searched April 2024; 4448 studies identified
- Epidemiological meta-analysis
- Cochrane Central, PubMed, MEDLINE and EMBASE searched April 2024; 4448 studies identified
Pooled result
As reported in the abstract
Combined in-hospital and 30-day mortality, unadjusted
Odds ratio
1.35
95% CI 1.26–1.44
P < 0.001
By group
Women vs Men
OR 1.35 (95% CI 1.26–1.44); P < 0.001
Further pooled results
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Combined in-hospital/30-day mortality, studies reporting adjusted ORsAdjusted | 1.10 (1.06–1.15) | P < 0.001 | |
| Mechanical circulatory support use | 0.67 (0.57–0.79) | P < 0.001 | |
| Intra-aortic balloon pump use | 0.79 (0.71–0.89) | P < 0.001 | |
| ECMO use | 0.84 (0.71–0.99) | P = 0.045 | |
| 0.512Odds ratio (log scale) |
Mortality, AMI- and HF-related cardiogenic shock (subgroups)
- Effects remained consistent across subgroups of acute myocardial infarction- and HF-related cardiogenic shock
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Sex differences in treatments and outcomes of patients with cardiogenic shock: a systematic review and epidemiological meta-analysis. Crit Care. Published 6 June 2024. doi:10.
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