Neuroanesthesia & neurocritical care
Sex-related differences in adult patients with status epilepticus: a seven-year two-center observation
Authors' conclusion
This study identified sex-related disparities in the clinical features, treatment modalities, and outcome of adult patients with SE with women being at a disadvantage
Study context
- Population
- Adults treated for SE at two Swiss academic centres (Basel, Geneva), 2015–202145.9% women
- Participants
- 762 adults
- Exposure
- Women vs men
- Outcome
- Return to premorbid neurologic function, death during hospital stay and at 30 days
Methodological detailstwo-centre, multivariable logistic regression, propensity-score matched analysis
- Two-centre
- Multivariable logistic regression
- Propensity-score matched analysis
Main finding
As reported in the abstract
Return to premorbid neurologic function, in-hospital and 30-day death
- Unmatched multivariable analyses: age, but not female sex, associated with all primary outcomes
- Propensity score-matched multivariable analyses: decreased odds of return to premorbid neurologic function for women, independent of potential confounders
- Propensity score matching for age imbalance
Observational data: associations, not effects.
Secondary outcomes
Focal nonconvulsive SE without coma
P = 0.005
SE with motor symptoms
P = 0.002
Refractory SE
P = 0.898
Anaesthetised and mechanically ventilated
P = 0.001
Discharged home · hospital discharge
P < 0.001
Discharged to nursing home · hospital discharge
P = 0.004
| Outcome | Women | Men | P value |
|---|---|---|---|
| Median age | 70 | 66 | P = 0.003 |
| SE duration | 1 day | 0.5 days | P = 0.011 |
Intracranial haemorrhage
- Lower frequency in women
Original publication
Sex-related differences in adult patients with status epilepticus: a seven-year two-center observation. Crit Care. Published 5 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →