Neuroanesthesia & neurocritical care
Significant perioperative parameters affecting postoperative complications within 30 days following craniotomy for primary malignant brain tumors
Authors' conclusion
Four parameters were demonstrated to significantly influence the risk of PC1M in patients undergoing primary malignant brain tumor removal.
Study context
- Population
- Patients undergoing craniotomy for primary malignant brain tumor (WHO grades III and IV), Kaohsiung Veterans General Hospital, Taiwan, January 2011 to December 2020
- Participants
- 95 patients
- Exposure
- PC1M vs nonPC1M
- PC1Mn = 41
- Outcome
- Postoperative complications within 30 days (PC1M)
- Follow-up
- 30 days
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Independent risk factors for PC1M (stepwise logistic regression)
PC1M
41
events
Adjusted odds ratio (95% CI)P value
ASA score > 2
3.17(1.19–8.45)
P = 0.02124-h postoperative change in hematocrit by > - 4.8%
3.45(1.22–9.73)
P = 0.001924-h postoperative change in kinetic eGFR < 0 mL/min
3.99(1.52–10.53)
P = 0.005- Longer anesthesia duration · CI as printed does not contain the estimate
- aOR 1.16 (95% CI 0.69–0.88); P < 0.001
Observational data: associations, not effects.
Further findings
Kinetic eGFR reduction and PC1M, age ≥ 65 years (subgroup)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Age ≥ 65 years | 11.55 (1.30–102.79) | P = 0.028 | |
| 0.050.21520Odds ratio (log scale) |
- Kinetic eGFR reduction and PC1M, age ≥ 65 years (subgroup): reduction of kinetic eGFR more robustly associated with higher risk of PC1M
Original publication
Significant perioperative parameters affecting postoperative complications within 30 days following craniotomy for primary malignant brain tumors. Perioper Med (Lond). Published 23 October 2023. doi:10.
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