ICU sedation, delirium & recovery
Sleep quality and quantity determined by polysomnography in mechanically ventilated critically ill patients randomized to dexmedetomidine or placebo
Authors' conclusion
Total sleep time and sleep efficiency were significantly increased, without elimination of REM sleep, in mechanically ventilated ICU patients randomized to dexmedetomidine, when compared to a control PSG recording performed during non-sedation/standard care.
Study context
- Population
- Mechanically ventilated critically ill ICU patients
- Participants
- 30 consecutive patients
- Comparison
- Dexmedetomidine vs placebo, each vs own control polysomnography (PSG) recording
- Dexmedetomidinen = 20
- Placebon = 10reference
- Primary endpoint
- Sleep quality, total sleep time (TST), sleep efficiency (SE) and REM sleep by polysomnography (PSG)
Methodological detailsdouble-blinded, placebo-controlled, two parallel groups, Two 16 h PSG recordings per patient on two consecutive nights; randomised after the first recording (control recording)
- Double-blinded
- Placebo-controlled
- Two parallel groups
- Two 16 h PSG recordings per patient on two consecutive nights; randomised after the first recording (control recording)
Primary result
As reported in the abstract
SE and TST (PSG), change vs control recording
SE increase
37.6% (29.7;45.6) vs 3.7% (−11.4;18.8)
P < 0.001
Dexmedetomidine
Total sleep time (TST) prolongation
271 (210;324) vs 27 (−82;135) min.
P < 0.001
Dexmedetomidine
Secondary outcomes
Delirium, physical activity, RASS score
- No significant difference, except for RASS night two
Original publication
Sleep quality and quantity determined by polysomnography in mechanically ventilated critically ill patients randomized to dexmedetomidine or placebo. Acta Anaesthesiol Scand. Published 21 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →