Sleep quality as a mediator of the relation between depression and chronic pain: a systematic review and meta-analysis
Authors' conclusion
Sleep disturbance partially mediates the association between depression and pain.
Study context
- Population
- Cohort and case-control studies on depression, sleep disturbance and chronic pain
- Participants
- 120,489 participants · 49 studies
- Outcome
- Indirect (mediation) effect of sleep disturbance on the depression–chronic pain association (pooled path coefficient)
Methodological detailstwo-stage meta-analytic structural equation modelling, subgroup analyses
- Two-stage meta-analytic structural equation modelling
- Subgroup analyses
Pooled result
As reported in the abstract
Indirect effect of sleep disturbance (depression → chronic pain)
Pooled path coefficient of indirect effect
0.03
95% CI 0.01–0.05
Proportion of total effect of depression on chronic pain
12.5%
Further pooled results
Indirect effect, cohort studies (subgroup)
- Path coefficient
- 0.02 (95% CI: 0.002-0.04)
Indirect effect, European studies (subgroup)
- Path coefficient
- 0.03 (95% CI: 0.004-0.05)
Indirect effect, studies adjusted for confounders (subgroup)
- Path coefficient
- 0.04 (95% CI: 0.01-0.09)
Original publication
Sleep quality as a mediator of the relation between depression and chronic pain: a systematic review and meta-analysis. Br J Anaesth. Published 12 April 2023. doi:10.
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