Cardiac arrest & resuscitation
Sodium bicarbonate administration is associated with improved survival in asystolic and pulseless electrical activity (PEA) Out-of-Hospital cardiac arrest
Authors' conclusion
Bicarb was associated with survival in non-shockable rhythms and ROSC in asystole.
Study context
- Population
- Non-traumatic out-of-hospital cardiac arrest (OHCA) with resuscitation lasting 5–40 minutes, stratified by presenting rhythm (VF/VT, PEA, asystole), ESO Data Collaborative 2019–2020records analysed
- Participants
- 23,567 participants
- Exposure
- Sodium bicarbonate vs no bicarbonate in OHCA
- Bicarbn = 6,663
- Outcome
- Any prehospital ROSC and survival to discharge
Methodological detailspropensity-score matched, prehospital EHR database (1,322 agencies, 50 states)
- Propensity-score matched
- Prehospital EHR database (1,322 agencies, 50 states)
Main finding
As reported in the abstract
ROSC and survival to discharge, by presenting rhythm (propensity-matched)
uOR
1.23
95 % CI 1.04–1.44
ROSC, asystole
uOR
1.40
95 % CI 1.05–1.87
survival, asystole
uOR
1.54
95 % CI 1.03–2.31
survival, PEA
Bicarb
- ROSC, asystole
- 10.6 %
- Survival, asystole
- 3.3 %
- Survival, PEA
- 8.1 %
Control
- ROSC, asystole
- 8.8 %
- Survival, asystole
- 2.4 %
- Survival, PEA
- 5.4 %
ROSC, asystole
Bicarb10.6 %
Control8.8 %
Survival, asystole
Bicarb3.3 %
Control2.4 %
Survival, PEA
Bicarb8.1 %
Control5.4 %
Observational data: associations, not effects.
Original publication
Sodium bicarbonate administration is associated with improved survival in asystolic and PEA Out-of-Hospital cardiac arrest. Resuscitation. Published 18 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →