Organ support & nutrition

STARDaki: a consensus-based STARD extension for standardized reporting of diagnostic accuracy in acute kidney injury

Intensive Care MedPublished Systematic review with modified Delphi expert consensus

Authors' conclusion

Most studies examining AKI biomarker performance fail to conform to the STARD standards for reporting, leading to poor diagnostic accuracy estimates and reduced clinical applicability and generalizability.

Study context

Population
Diagnostic test accuracy (DTA) studies of acute kidney injury (AKI) biomarkers published before February 2025
Participants
122 DTA studies
Outcome
Quality and reporting of AKI biomarker DTA studies
Methodological detailsQUADAS-2 quality assessment, STARD 2015 checklist, international 17-member expert panel, modified Delphi process
  • QUADAS-2 quality assessment
  • STARD 2015 checklist
  • International 17-member expert panel
  • Modified Delphi process

Recommendations

As reported in the abstract

DTA studies identified
122
Insufficiently reported
15
Remaining studies
107
Reported AKI diagnosis within 48 h of sampling
19
High-quality by QUADAS-2 (of these)
16

Further findings

Expert panel consensus (STARDaki)

Panel agreed criteria for patient selection, reference standards and reporting of test-retest reliability to supplement STARD for AKI biomarker studies

Original publication

STARDaki: a consensus-based STARD extension for standardized reporting of diagnostic accuracy in acute kidney injury. Intensive Care Med. Published 28 July 2026. doi:10.1007/s00134-026-08549-5

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