Neuroanesthesia & neurocritical care
Cerebro-spinal fluid glucose and lactate concentrations changes in response to therapies in patIents with primary brain injury: the START-TRIP study
Authors' conclusion
In this study, CGLR significantly changed over time, regardless of the study group. However, these effects were more significant in those patients receiving interventions to reduce ICP.
Study context
- Population
- Adults (> 18 years) with acute brain injury and an external ventricular drain (EVD) for intracranial pressure (ICP) monitoring inserted within 24 h of admission, 12 intensive care units (ICUs)
- Participants
- 219 adults · 12 ICUs
- Exposure
- Interventions to reduce ICP vs normal ICP
- Interventionn = 115
- Outcome
- Cerebrospinal fluid (CSF) glucose-to-lactate ratio (CGLR) changes
- Follow-up
- 2 h after intervention
Methodological detailsmulticentre, 12 ICUs, September 2017 to March 2022
- Multicentre
- 12 ICUs, September 2017 to March 2022
Main finding
As reported in the abstract
Change in CGLR
Intervention
20.2%
Control
1.6%
P = 0.001
Observational data: associations, not effects.
Further findings
ICP and CPP (Intervention)
- ICP significantly decreased and CPP increased
Correlation between ICP and CSF glucose-to-lactate ratio (CGLR) changes (Intervention)
- Weak inverse correlation
Original publication
Cerebro-spinal fluid glucose and lactate concentrations changes in response to therapies in patIents with primary brain injury: the START-TRIP study. Crit Care. Published 31 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →