Sugammadex versus cholinesterase inhibitors to antagonize respiratory dysfunction after neuromuscular blockade in patients undergoing pulmonary surgery: a systematic review and meta-analysis
Pooled result · Postoperative respiratory complicationsResult — go to the resultRelative risk 0.77 95% CI 0.66–0.90Authors' conclusion
Compared with traditional muscle relaxant antagonists, the use of sugammadex after thoracic surgery can help reverse the respiratory dysfunction related to residual muscle relaxants and reduce the risk of atelectasis, pneumonia, and reintubation.
Study context
- Population
- Patients undergoing thoracic (pulmonary) surgery with neuromuscular blockade
- Participants
- 1,445 patients · 11 studies
- Comparison
- Sugammadex vs cholinesterase inhibitors
- Outcome
- Postoperative respiratory complications
Pooled result
As reported in the abstract
Relative risk
0.77
95% CI 0.66–0.90
Sugammadex vs Cholinesterase inhibitors
RR 0.77 (95% CI 0.66–0.90)
Further pooled results
| Outcome | RR (95% CI) | |
|---|---|---|
| AtelectasisSugammadex vs Cholinesterase inhibitors | 0.61 (0.47–0.79) | |
| PneumoniaSugammadex vs Cholinesterase inhibitors | 0.64 (0.46–0.91) | |
| 0.512Relative risk (log scale) |
Extubation period (subgroups by age, surgery type, anaesthesia duration, BMI)
- Sugammadex associated with shortened extubation period
- P ≤ 0.005
Pleural effusion and pneumothorax
- No difference in risk
Original publication
Sugammadex versus cholinesterase inhibitors to antagonize respiratory dysfunction after neuromuscular blockade in patients undergoing pulmonary surgery: a systematic review and meta-analysis. Perioper Med (Lond). Published 10 July 2025. doi:10.
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