Surviving Sepsis Campaign Research Priorities 2023
Methodological detailsexpert committee, iterative consensus
- Expert committee
- Iterative consensus
Recommendations
As issued by the authors
- Clinical priority 1
Best strategy for screening and identification of sepsis; can predictive modeling assist real-time recognition?
- Clinical priority 2
What causes organ injury and dysfunction in sepsis, how should it be defined and detected?
- Clinical priority 3
How should fluid resuscitation be individualized initially and beyond?
- Clinical priority 4
Best vasopressor approach for the different phases of septic shock?
- Clinical priority 5
Can a personalized/precision medicine approach identify optimal therapies to improve outcomes?
- Basic science priority 1
How to improve animal models to more closely resemble human sepsis?
- Basic science priority 2
Which outcome variables maximize correlations between human sepsis and animal models?
- Basic science priority 3
How does sepsis affect the brain, how do brain alterations contribute to organ dysfunction, and how does sepsis affect neural, endocrine and immune interactions?
- Basic science priority 4
How does the microbiome affect sepsis pathobiology?
- Basic science priority 5
How do genetics and epigenetics influence sepsis development, course and treatment response?
Original publication
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