Hemodynamics, fluids & transfusion
SvO₂ response to red blood cell transfusion in cardiovascular surgical icu patients: a retrospective observational study
Main finding · SvO₂ responseResult — go to the resultAdjusted odds ratio 0.89 95% CI 0.86–0.91Authors' conclusion
Lower pre-transfusion SvO₂ was associated with acute individual-level SvO₂ increase after transfusion, but mean SvO₂ change was minimal. The association did not establish tissue oxygenation or clinical benefit and does not support using SvO₂, including the 69% cutoff, as a transfusion indication or trigger.
Study context
- Population
- Adult cardiovascular surgical ICU patients receiving one red blood cell (RBC)-equivalent transfusion with pre-transfusion hemoglobin (Hb) ≥ 7.5 g/dL and paired pre- and post-transfusion SvO₂
- Participants
- 1,352 patients
- Exposure
- SvO₂ before vs ≈60 min after one RBC-equivalent transfusion
- Outcome
- Individual-level SvO₂ response (ΔSvO₂ ≥5% points from baseline), defined a priori
- Follow-up
- ≈60 min after transfusion initiation
Methodological detailssingle-center
- Single-center
Main finding
SvO₂ response
Adjusted odds ratio
0.89
95% CI 0.86–0.91
P < 0.001
Per 1% increase, as printed
As reported in the abstract
- AUC of pre-transfusion SvO₂ for SvO₂ response
- 0.778 (95% CI 0.740-0.816)
- Youden-derived cutoff of pre-transfusion SvO₂ (exploratory, not a transfusion trigger)
- 69%
Observational data: associations, not effects.
Further findings
Hb, pre- vs post-transfusion
- Mean Hb increased from 9.82 ± 0.92 to 10.24 ± 0.98 g/dL
SvO₂, cohort level, pre- vs post-transfusion
- Mean SvO₂ changed minimally, from 73.79 ± 9.91% to 73.86 ± 9.37%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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