Systemic inflammation and delirium during critical illness
Authors' conclusion
Markers of inflammation and possibly endogenous anticoagulant activity are associated with delirium and coma during critical illness.
Study context
- Population
- Adults with respiratory failure and/or shock in medical or surgical intensive care units (ICUs) at 5 centres
- Participants
- 991 adults
- Outcome
- Delirium or coma vs normal mental status the following day (Richmond Agitation Sedation Scale (RASS), Confusion Assessment Method-Intensive Care Unit (CAM-ICU)), by biomarker concentrations
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Delirium the following day
Odds ratio (95% CI)
Higher IL-6
1.8(1.4–2.3)
Higher IL-8
1.3(1.1–1.5)
Higher IL-10
1.5(1.2–1.8)
Higher TNF-α
1.2(1.0–1.4)
Higher TNFR1
1.3(1.1–1.6)
Lower protein C
0.7(0.6–0.8)
Observational data: associations, not effects.
Further findings
Coma the following day
| OR (95% CI) | ||
|---|---|---|
| Higher CRP | 1.4 (1.1–1.7) | |
| Higher IFN-γ | 1.3 (1.1–1.5) | |
| Higher IL-6 | 2.3 (1.8–3.0) | |
| Higher IL-8 | 1.8 (1.4–2.3) | |
| Higher IL-10 | 1.5 (1.2–2.0) | |
| Lower protein C | 0.6 (0.5–0.8) | |
| 0.20.5125Odds ratio (log scale) |
Mental status
- IL-1β, IL-12 and MMP-9 not associated with mental status
Original publication
Systemic inflammation and delirium during critical illness. Intensive Care Med. Published 22 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →