Target attainment of beta-lactam antibiotics and ciprofloxacin in critically ill patients and its association with 28-day mortality
Authors' conclusion
A high rate of target attainment (100 % ƒT>1xECOFF) for beta-lactams and a lower rate for ciprofloxacin was observed. Achieving exposures of 100 % ƒT>4xECOFF was associated with 28-day mortality.
Study context
- Population
- Critically ill patients receiving beta-lactams or ciprofloxacin
- Participants
- 292 vs 94
- Comparison
- Target attainment vs non-attainment
- Beta-lactamsn = 292
- Ciprofloxacinn = 94
- Primary endpoint
- Pharmacodynamic target attainment (100 % ƒT>1xECOFF for beta-lactams; fAUC0-24h/ECOFF>125 for ciprofloxacin)
- Follow-up
- First 36 h (T1)
Primary result
As reported in the abstract
Target attainment rate · T1
Further findings
28-day mortality, beta-lactams, by attainment of 100 % ƒT>1xECOFF · significantly higher
P = 0.01
28-day mortality, multivariate analysis
| OR (95 % CI) | ||
|---|---|---|
| 100 % ƒT>4xECOFFAssociated with higher 28-day mortality · multivariate analysis | 2.70 (1.36–5.48) | |
| 100 % ƒT>1xECOFFNot associated · multivariate analysis | 1.28 (0.53–3.34) | |
| 0.20.5125Odds ratio (log scale) |
Factors associated with target attainment
- Lower eGFR and higher SOFA score associated with target attainment
Original publication
Target attainment of beta-lactam antibiotics and ciprofloxacin in critically ill patients and its association with 28-day mortality. J Crit Care. Published 14 September 2024. doi:10.
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