Neuroanaesthesia & neurocritical care

Temperature control in acute brain injury

Intensive Care MedPublished Narrative review

Authors' conclusion

Temperature control is a fundamental component of care aimed at protecting the injured brain through continuous monitoring, early detection of fever, and prevention of temperature-related harm.

Study context

Population
Patients with acute brain injury (TBI, acute vascular brain injury, post-cardiac arrest encephalopathy) in neurocritical care
Outcome
Temperature management in acute brain injury

Main finding

As reported in the abstract

  • Fever consistently associated with worse neurological outcomes
  • TBI: hypothermia reduces ICP but does not improve functional outcome when prophylactic; reserved for refractory intracranial hypertension
  • Acute vascular brain injury: neutral trials and feasibility constraints shifted practice toward early detection and treatment of fever rather than hypothermia
  • Post-cardiac arrest: guidelines recommend protocolised temperature control with a constant target between 32°C and 37.5°C and active fever prevention, rather than mandatory hypothermia

Original publication

Temperature control in acute brain injury. Intensive Care Med. Published 20 April 2026. doi:10.1007/s00134-026-08367-9

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