ICU sedation, delirium & recovery
Temporal trends and prognostic factors in critically ill adult patients with acute leukemia: an individual participant data meta-analysis
Authors' conclusion
In this large international individual participant meta-analysis, survival of critically ill patients with acute leukemia improved over time, particularly among those requiring mechanical ventilation. Age and the need for mechanical ventilation and other life-sustaining therapies remain strong, independent predictors of ICU mortality.
Study context
- Population
- Critically ill adults with acute leukemia admitted to the intensive care unit (ICU), excluding prior allogeneic hematopoietic stem cell transplantation
- Participants
- 2,003 adults · 55 ICUs · 19 countries
- Outcome
- ICU mortality (temporal trends and prognostic factors)
Methodological detailsmixed-effects logistic regression, international
- Mixed-effects logistic regression
- International
Pooled result
As reported in the abstract
Factors associated with ICU mortality
Estimate (95% CI)
Age > 65 years
OR 1.98(1.49–2.64)
AML
OR 1.70(1.23–2.34)
Admission during diagnosis or induction chemotherapy
OR 1.50(1.08–2.07)
Relapsed or refractory disease
OR 2.08(1.36–3.21)
Need for mechanical ventilation
OR 6.46(4.84–8.63)
Need for other life-sustaining therapies
OR 2.21(1.62–3.02)
Year of ICU admission, ventilated patientsimproved survival only among ventilated patients
OR per additional year 0.93(0.93–0.93)
- Crude ICU mortality overall
- 45%
- Crude ICU mortality among ventilated patients
- 66%
Original publication
Temporal trends and prognostic factors in critically ill adult patients with acute leukemia: an individual participant data meta-analysis. Intensive Care Med. Published 4 May 2026. doi:10.
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