Temporal trends in critical care burden and outcomes of Andes virus-associated hantavirus cardiopulmonary syndrome: a national Chilean cohort
Authors' conclusion
HCPS caused by Andes virus remains associated with high in-hospital mortality and substantial amounts of respiratory support, particularly MV and ECMO. Moreover, the COVID-19 pandemic was associated with a significant increase in HCPS mortality.
Study context
- Population
- Patients admitted with Andes virus hantavirus cardiopulmonary syndrome (HCPS) in 31 Chilean hospitals, 2019–2024
- Participants
- 215 patients · 31 hospitals
- Exposure
- Patients stratified by maximal respiratory support: none, non-invasive ventilation (NIV), invasive mechanical ventilation (MV) or extracorporeal membrane oxygenation (ECMO); pre-COVID-19, pandemic and post-pandemic periods
- Outcome
- Hospital LOS and in-hospital mortality
Methodological detailsnational, multicentre, administrative database (Diagnosis-Related Groups)
- National
- Multicentre
- Administrative database (Diagnosis-Related Groups)
Main finding
As reported in the abstract
Hospital LOS and in-hospital mortality (whole cohort)
Hospital length of stay (LOS), days
8
3–15
In-hospital mortality
20.5%
Observational data: associations, not effects.
Further findings
In-hospital mortality by period
| aOR (CI) | P value | ||
|---|---|---|---|
| Pandemic periodIndependently associated | 2.73 (1.06–7.63) | P = 0.045 | |
| 0.10.31310Adjusted odds ratio (log scale) |
| Outcome | NIV | MV | ECMO |
|---|---|---|---|
| Case fatality rate by maximal respiratory support | — not stated in the abstract | 29.6% | 32.9% |
| Respiratory support use among 148 patients requiring support | 14.2% | 36.5% | 49.3% |
— not stated in the abstract
Original publication
Temporal trends in critical care burden and outcomes of Andes virus-associated hantavirus cardiopulmonary syndrome: a national Chilean cohort. Intensive Care Med. Published 2 September 2026. doi:10.
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