Cardiac arrest & resuscitation
Temporal trends in treatment and outcomes of patients with cardiac arrest due to pulmonary embolism: a nationwide inpatient database study
Authors' conclusion
From 2012 to 2024, TL use decreased, whereas ECMO use increased. The survival and neurological outcomes improved over time, particularly in patients with hospital-acquired PE and those who received ECMO.
Study context
- Population
- Patients with pulmonary embolism (PE) who underwent CPR (PE-related cardiac arrest), nationwide inpatient database in Japan, 2012–2024
- Participants
- 10,390 patients
- Outcome
- Co-primary: survival to hospital discharge and favorable neurological outcomes at discharge
- Follow-up
- Hospital discharge
Methodological detailsnationwide inpatient database, temporal trend analysis
- Nationwide inpatient database
- Temporal trend analysis
Main finding
As reported in the abstract
Overall survival to hospital discharge
22.5%
Overall favorable neurological outcomes at discharge
18.5%
Survival increased from 2012 to 2023
20.9% to 24.1%
p = 0.04
Favorable neurological outcomes increased from 2012 to 2023
17.4% to 20.6%
p = 0.04
Observational data: associations, not effects.
Further findings
Treatment patterns and temporal trends
- Extracorporeal membrane oxygenation (ECMO) use overall
- 18.4%
- TL use overall
- 11.1%
- TL use decreased from 2012 to 2023
- 16.0% to 6.7% (p < 0.001)
- ECMO use increased from 2012 to 2023
- 16.0% to 20.8% (p = 0.015)
Trends in survival and neurological outcomes, hospital-acquired PE and ECMO-treated (subgroup)
- Improvements particularly evident in patients with hospital-acquired PE and those treated with ECMO
Patient characteristics
- Median age, years
- 74
- Men
- 44.4%
Original publication
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