Properties of testosterone transdermal gel in restoring serum testosterone levels in critically ill patients: the TestICU-1 pilot study
Authors' conclusion
The administration of T-gel did not increase significantly the percentage of patients with normal serum T values as compared to control.
Study context
- Population
- Intensive care unit (ICU) patients receiving vasopressors and mechanical ventilation for at least 2 days; excluding prostate or breast cancer, PSA >4 ng/mL, age ≥ 80 years19 (63 %) men
- Participants
- 30 patients
- Comparison
- Testosterone transdermal gel for 14 days vs control
- Primary endpoint
- Percentage of patients with serum Total T value within normal ranges
- Follow-up
- Days 4, 7, 10 and 14
Methodological detailsopen, monocentric, pilot
- Open
- Monocentric
- Pilot
Primary result
As reported in the abstract
- Percentage of patients with normal serum Total T did not differ between T and controls
Further findings
Serum Total T within normal range at inclusion
- None of the men and half of the women within normal range
Safety
Cardiovascular events and cytolysis
- No significant differences between groups
Original publication
Properties of testosterone transdermal gel in restoring serum testosterone levels in critically ill patients: the TestICU-1 pilot study. J Crit Care. Published 15 November 2025. doi:10.
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