Pediatric anesthesia & critical care
The Association Between Central Line-Associated Bloodstream Infection and Central Line Access*
Main finding · CLABSI in the next 3 days per daily CL accessResult — go to the resultAdjusted odds ratio 1.007 95% CI 1.003–1.012Authors' conclusion
The number of daily CL accesses is independently associated with risk of CLABSI in the next 3 days. In the pediatric population examined, most medications delivered through CLs could be safely administered peripherally.
Study context
- Population
- Patients with at least one central line (CL) device day, 395-bed pediatric academic medical center, 2015–2019138,411 CL device days
- Participants
- 6,543 patients
- Exposure
- Number of CL accesses per CL device day
- Outcome
- CLABSI within the following 3 days
- Follow-up
- 3 days
Methodological detailssingle-centre, multivariate mixed-effects logistic regression
- Single-centre
- Multivariate mixed-effects logistic regression
Main finding
CLABSI in the next 3 days per daily CL access
Adjusted odds ratio
1.007
95% CI 1.003–1.012
P = 0.002
Per-day CL accesses
aOR 1.007 (95% CI 1.003–1.012); P = 0.002
Per-day CL accesses, as printed
As reported in the abstract
Observational data: associations, not effects.
Further findings
CLABSI events
- Device days within 3 days of a CLABSI
- 639
- Total central line-associated bloodstream infections (CLABSIs)
- 217
CL medications that were candidates for peripheral delivery
- Candidates for delivery through a peripheral line
- 88%
- Average contribution of these accesses to daily CLABSI risk (increase)
- 6.3%
Original publication
The Association Between Central Line-Associated Bloodstream Infection and Central Line Access*. Crit Care Med. Published 15 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →