Pediatric anesthesia & critical care
The association between early arterial oxygen and carbon dioxide with neurologic outcomes after pediatric ECPR in children with cardiac disease
An erratum to this article was published (Resuscitation, Sep 2026 ↗)
Authors' conclusion
In children with cardiac disease, early arterial oxygen changes may have a stronger association with SHD with favorable neurological outcome than carbon dioxide fluctuations.
Study context
- Population
- Children with cardiac disease undergoing ECPR in a single-centre pediatric cardiac ICU, 2010–2022
- Participants
- 78 index ECPR events
- Exposure
- Early post-ECPR change in PaO2 and PaCO2 category during first 6 h
- Outcome
- Survival to hospital discharge with favorable neurological outcome (Pediatric Cerebral Performance Category 1, 2, 3 or no change from baseline)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Median [IQR] change in PaO2
+127.5
93, 184.7
Observational data: associations, not effects.
Secondary outcomes
Overall survival to hospital discharge (SHD)
- Smaller changes in PaO2 associated with higher odds of overall SHD
- Hypocarbia vs normocarbia associated with higher odds of overall SHD
Neuroimaging injury
- Associated with hypercarbia vs hypocarbia
Original publication
The association between early arterial oxygen and carbon dioxide with neurologic outcomes after pediatric ECPR in children with cardiac disease. Resuscitation. Published 9 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →